Structural adaptations of lactate dehydrogenase isozymes.
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چکیده
منابع مشابه
Amino- and carboxyl-terminal analyses of hepatoma lactate dehydrogenase isozymes.
The M4 isozyme of lactate dehydrogenase was purified to homogeneity from normal rat liver and from two Morris hepatomas (7777 and 7793). Amino-terminal analyses with fluorodinitrobenzene failed to detect the presence of free amino-terminal residues in each enzyme studied. Each enzyme contained between 3.7 and 4.1 moles of protein-bound acetyl groups per mole of enzyme. The amino-terminal peptid...
متن کاملGenetic Evidence for the Subunit Structure of Lactate Dehydrogenase Isozymes.
The lactate dehydrogenases commonly occur in from one to five molecular forms (isozymes) in the various tissues of an animal species.' By means of zone electrophoresis, characteristic patterns of these isozymes may be demonstrated in each tissue. In adult animals, most tissues contain all five isozymes but in different proportions. Usually, heart muscle exhibits principally the first, or most n...
متن کاملLactic Dehydrogenase Isozymes
Lactic dehydrogenase isozymes (I-lactate, NAD oxidoreductase), which are key enzymes in glycolysis, have been the object of extensive investigation. Five LDH isozymes have been found. The five isozymes represent the five possible tetramaric combinations of the two polypeptides. Thus, the five tetramers range from LDH-l( H4 ) to LDH -5 ( M4 ), the three hybrid enzymes being H3MI, H2 M2, and H j ...
متن کاملLactate Dehydrogenase Isozymes of Salmonid Fish EVIDENCE FOR UNIQUE AND RAPID FUNCTIONAL DIVERGENCE OF DUPLICATED H, LACTATE DEHYDROGENASES*
Salmonid fish, as a result of total genome duplication, have two genes, Ldh H and Ldh H’, coding for polypeptides H and H’, respectively, both of which have been shown in their tetrameric forms to be immunologically related to the classical Hq lactate dehydrogenase isozyme of higher vertebrates (BAILEY, G. S., AND WILSON, A. C. (1968) J. Biol. Chem. 243, 5843). The H4 and H’4 isozymes have now ...
متن کاملLactate Dehydrogenase Isozymes of Salmonid Fish EVIDENCE FOR UNIQUE AND RAPID FUNCTIONAL DIVERGENCE OF DUPLICATED H, LACTATE
Salmonid fish, as a result of total genome duplication, have two genes, Ldh H and Ldh H’, coding for polypeptides H and H’, respectively, both of which have been shown in their tetrameric forms to be immunologically related to the classical Hq lactate dehydrogenase isozyme of higher vertebrates (BAILEY, G. S., AND WILSON, A. C. (1968) J. Biol. Chem. 243, 5843). The H4 and H’4 isozymes have now ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1977
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.74.7.2677